"The dearest of our possessions": applying Floridi's information privacy concept in models of information behavior and information literacy

This conceptual paper argues for the value of an approach to privacy in the digital information environment informed by Luciano Floridi's philosophy of information and information ethics. This approach involves achieving informational privacy, through the features of anonymity and obscurity, through an optimal balance of ontological frictions. This approach may be used to modify models for information behavior and for information literacy, giving them a fuller and more effective coverage of privacy issues in the infosphere. For information behavior, the Information Seeking and Communication Model, and the Information Grounds conception, are most appropriate for this purpose. For information literacy, the metaliteracy model, using a modification a privacy literacy framework, is most suitable

Big data, method and the ethics of location : a case study of a hookup app for men who have sex with men

With the rise of geo-social media, location is emerging as a particularly sensitive data point for big data and digital media research. To explore this area, we reflect on our ethics for a study in which we analyze data generated via an app that facilitates public sex among men who have sex with men. The ethical sensitivities around location are further heightened in the context of research into such digital sexual cultures. Public sexual cultures involving men who have sex with men operate both in spaces “meant” for public sex (e.g., gay saunas and dark rooms) and spaces “not meant” for public sex (e.g., shopping centers and public toilets). The app in question facilitates this activity. We developed a web scraper that carefully collected selected data from the app and that data were then analyzed to help identify ethical issues. We used a mixture of content analysis using Python scripts, geovisualisation software and manual qualitative coding techniques. Our findings, which are methodological rather than theoretical in nature, center on the ethics associated with generating, processing, presenting, archiving and deleting big data in a context where harassment, imprisonment, physical harm and even death occur. We find a tension in normal standards of ethical conduct where humans are involved in research. We found that location came to the fore as a key - though not the only - actor requiring attention when considering ethics in a big data context

Distilling Privacy Requirements for Mobile Applications

As mobile computing applications have become commonplace, it is increasingly important for them to address end-users’ privacy requirements. Privacy requirements depend on a number of contextual socio-cultural factors to which mobility adds another level of contextual variation. However, traditional requirements elicitation methods do not sufficiently account for contextual factors and therefore cannot be used effectively to represent and analyse the privacy requirements of mobile end users. On the other hand, methods that do investigate contextual factors tend to produce data that does not lend itself to the process of requirements extraction. To address this problem we have developed a Privacy Requirements Distillation approach that employs a problem analysis framework to extract and refine privacy requirements for mobile applications from raw data gathered through empirical studies involving end users. Our approach introduces privacy facets that capture patterns of privacy concerns which are matched against the raw data. We demonstrate and evaluate our approach using qualitative data from an empirical study of a mobile social networking application

Strangers in the Room: Unpacking Perceptions of 'Smartness' and Related Ethical Concerns in the Home

The increasingly widespread use of 'smart' devices has raised multifarious ethical concerns regarding their use in domestic spaces. Previous work examining such ethical dimensions has typically either involved empirical studies of concerns raised by specific devices and use contexts, or alternatively expounded on abstract concepts like autonomy, privacy or trust in relation to 'smart homes' in general. This paper attempts to bridge these approaches by asking what features of smart devices users consider as rendering them 'smart' and how these relate to ethical concerns. Through a multimethod investigation including surveys with smart device users (n=120) and semi-structured interviews (n=15), we identify and describe eight types of smartness and explore how they engender a variety of ethical concerns including privacy, autonomy, and disruption of the social order. We argue that this middle ground, between concerns arising from particular devices and more abstract ethical concepts, can better anticipate potential ethical concerns regarding smart devices.Comment: 10 pages, 1 figure. To appear in the Proceedings of the 2020 ACM Conference on Designing Interactive Systems (DIS '20

Accelerating Discovery for Complex Neurological and Behavioral Disorders Through Systems Genetics and Integrative Genomics in the Laboratory Mouse

Recent advances in systems genetics and integrative functional genomics have greatly improved the study of complex neurological and behavioral traits. The methods developed for the integrated characterization of new, high-resolution mouse genetic reference populations and systems genetics enable behavioral geneticists an unprecedented opportunity to address questions of the molecular basis of neurological and psychiatric disorders and their comorbidities. Integrative genomics augment these strategies by enabling rapid informatics-assisted candidate gene prioritization, cross-species translation, and mechanistic comparison across related disorders from a wealth of existing data in mouse and other model organisms. Ultimately, through these complementary approaches, finding the mechanisms and sources of genetic variation underlying complex neurobehavioral disease related traits is becoming tractable. Furthermore, these methods enable categorization of neurobehavioral disorders through their underlying biological basis. Together, these model organism-based approaches can lead to a refinement of diagnostic categories and targeted treatment of neurological and psychiatric disease

Saving lives in road traffic—ethical aspects

Aim: This article aims at giving an overview of five ethical problem areas relating to traffic safety, thereby providing a general framework for analysing traffic safety from an ethical perspective and encouraging further discussion concerning problems, policies and technology in this area. Subjects and methods: The problems presented in the article are criminalisation, paternalism, privacy, justice and responsibility, and the reasons for choosing these are the following. First, they are all important areas in moral philosophy. Second, they are fairly general and it should be possible to categorise more specific problems under these headings. Ethical aspects of road traffic have not received the philosophical attention they deserve. Every year, more than 1 million people die globally in traffic accidents, and 20 to 50 million people are injured. Ninety per cent of the road traffic fatalities occur in low- and middle-income countries, where it is a growing problem. Politics, economics, culture and technology affect the number of fatalities and injuries, and the measures used to combat deaths in traffic as well as the role of road traffic should be ethically scrutinised. The topics are analysed and discussed from a moral-philosophical perspective, and the discussion includes both theory and applications. Results and conclusion: The author concludes with some thoughts on how the ethical discussion can be included in the public debate on how to save lives in road traffic. People in industrialised societies are so used to road traffic that it is almost seen as part of nature. Consequently, we do not acknowledge that we can introduce change and that we can affect the role we have given road traffic and cars. By acknowledging the ethical aspects of road traffic and illuminating the way the choices society makes are ethically charged, it becomes clear that there are alternative ways to design the road traffic system. The most important general conclusion is that discussion concerning these alternative ways of designing the system should be encouraged

Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy

Mitochondrial defects are a hallmark of early pathophysiology in Alzheimer’s disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity. Mitophagy constitutes a key pathway in mitochondrial quality control by which damaged mitochondria are targeted for autophagy. However, few details are known regarding the intersection of mitophagy and pathologies in tauopathy. Here, by applying biochemical and cell biological approaches including time-lapse confocal imaging in live tauopathy neurons, combined with gene rescue experiments via stereotactic injections of adeno-associated virus particles into tauopathy mouse brains, electrophysiological recordings and behavioural tests, we demonstrate for the first time that mitochondrial distribution deficits at presynaptic terminals are an early pathological feature in tauopathy brains. Furthermore, Parkin-mediated mitophagy is extensively activated in tauopathy neurons, which accelerates mitochondrial Rho GTPase 1 (Miro1) turnover and consequently halts Miro1-mediated mitochondrial anterograde movement towards synaptic terminals. As a result, mitochondrial supply at tauopathy synapses is disrupted, impairing synaptic function. Strikingly, increasing Miro1 levels restores the synaptic mitochondrial population by enhancing mitochondrial anterograde movement and thus reverses tauopathy-associated synaptic failure. In tauopathy mouse brains, overexpression of Miro1 markedly elevates synaptic distribution of mitochondria and protects against synaptic damage and neurodegeneration, thereby counteracting impairments in learning and memory as well as synaptic plasticity. Taken together, our study reveals that activation of the Parkin pathway triggers an unexpected effect—depletion of mitochondria from synaptic terminals, a characteristic feature of early tauopathy. We further provide new mechanistic insights into how parkin activation-enhanced Miro1 degradation and impaired mitochondrial anterograde transport drive tauopathy-linked synaptic pathogenesis and establish a foundation for future investigations into new therapeutic strategies to prevent synaptic deterioration in Alzheimer’s disease and other tauopathies

Spectacles of intimacy? Mapping the moral landscape of teenage social media

This paper explores young people's expressed concerns about privacy in the context of a highly mediated cultural environment, mapping social media practices against axes of visibility and participation. Drawing on interdisciplinary conceptual resources from both the humanities and social sciences, we use ‘spectacles of intimacy’ to conceptualise breaches of privacy, mapping an emergent moral landscape for young people that moves beyond concerns with e-safety to engage with the production and circulation of audiences and value. The paper draws on data from a methodological innovation project using multi-media and mixed methods to capture lived temporalities for children and young people. We present a model that captures a moral landscape shaped by emotional concerns about social media, the affordances of those media and affective discourses emerging from young people's use of the media

Bootstrapping Trust in Online Dating: Social Verification of Online Dating Profiles

Online dating is an increasingly thriving business which boasts billion-dollar revenues and attracts users in the tens of millions. Notwithstanding its popularity, online dating is not impervious to worrisome trust and privacy concerns raised by the disclosure of potentially sensitive data as well as the exposure to self-reported (and thus potentially misrepresented) information. Nonetheless, little research has, thus far, focused on how to enhance privacy and trustworthiness. In this paper, we report on a series of semi-structured interviews involving 20 participants, and show that users are significantly concerned with the veracity of online dating profiles. To address some of these concerns, we present the user-centered design of an interface, called Certifeye, which aims to bootstrap trust in online dating profiles using existing social network data. Certifeye verifies that the information users report on their online dating profile (e.g., age, relationship status, and/or photos) matches that displayed on their own Facebook profile. Finally, we present the results of a 161-user Mechanical Turk study assessing whether our veracity-enhancing interface successfully reduced concerns in online dating users and find a statistically significant trust increase.Comment: In Proceedings of Financial Cryptography and Data Security (FC) Workshop on Usable Security (USEC), 201

GeneWeaver: a web-based system for integrative functional genomics

High-throughput genome technologies have produced a wealth of data on the association of genes and gene products to biological functions. Investigators have discovered value in combining their experimental results with published genome-wide association studies, quantitative trait locus, microarray, RNA-sequencing and mutant phenotyping studies to identify gene-function associations across diverse experiments, species, conditions, behaviors or biological processes. These experimental results are typically derived from disparate data repositories, publication supplements or reconstructions from primary data stores. This leaves bench biologists with the complex and unscalable task of integrating data by identifying and gathering relevant studies, reanalyzing primary data, unifying gene identifiers and applying ad hoc computational analysis to the integrated set. The freely available GeneWeaver (http://www.GeneWeaver.org) powered by the Ontological Discovery Environment is a curated repository of genomic experimental results with an accompanying tool set for dynamic integration of these data sets, enabling users to interactively address questions about sets of biological functions and their relations to sets of genes. Thus, large numbers of independently published genomic results can be organized into new conceptual frameworks driven by the underlying, inferred biological relationships rather than a pre-existing semantic framework. An empirical ‘ontology’ is discovered from the aggregate of experimental knowledge around user-defined areas of biological inquiry